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KMID : 0988920080060010085
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Intestinal Research
2008 Volume.6 No. 1 p.85 ~ p.89
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A Case of Ulcerative Colitis with Prolonged Remission Following Azathioprine-Induced Pancytopenia
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Lee Jun-Seok
Park Young-Sook
Kim Nam-In
Jo Yun-Ju
Kim Seong-Hwan
Lee Han-Hyo
Song Moon-Hee
Jun Dae-Won
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Abstract
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Azathioprine (AZA) is widely used for the treatment of inflammatory bowel disease. Bone marrow suppression is a common side effect with AZA treatment. However, data from AZA trials has indicated that a leukocyte count less than 5,000/mm3 was a good predictor of induction and maintenance of remission. Moreover, there is evidence that eradication of sensitized leukocytes by leukapheresis or bone marrow transplantation improves inflammatory bowel disease. We report a case of a patient who had a chronic relapse of ulcerative colitis requiring the frequent use of systemic steroids, but presented prolonged remission following AZA-induced severe pancytopenia. Also colonoscopy showed accelerated healing of diffuse active ulcers following just recovery from pancytopenia.
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KEYWORD
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Azathioprine, Pancytopenia, Colitis, Ulcerative
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